产品货号：
Z21641
中文名称：
Nicastrin/NCSTN抗体
英文名称：
Anti-Nicastrin/NCSTN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Nicastrin/NCSTN Antibody |
| 指标别名 | APH2;KIAA0253;NCSTN;nicastrin |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | NCSTN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Nicastrin(72-88aa VIHVVEKEEDLQWVLTD),different from the related mouse sequence by one amino acid,and from the related rat sequence by two amino acids. |
| 实际分子量 | 120KD/140KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Nicastrin,also known as NCSTN,is a protein that is a part of the gamma secretase protein complex.It is mapped to 1q23.2.This gene is not catalytically active,but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase protein complex,all of which undergo significant post-translational modification before becoming active in the cell.NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.The encoded protein cleaves integral membrane proteins,including Notch receptors and beta-amyloid precursor protein,and may be a stabilizing cofactor required for gamma-secretase complex assembly.The cleavage of beta-amyloid precursor protein yields amyloid beta peptide,the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease.Nicastrin has also been identified as a regulator of neprilysin,an enzyme involved in the degradation of amyloid beta fragment. |
| Uniprot ID | Q92542 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | nicastrin |
| 蛋白名全称 | Nicastrin |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：Nicastrin/NCSTN抗体，Nicastrin抗体，NCSTN多抗，Anti-Nicastrin/NCSTN Antibody